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Spontaneous cyto toxic t cells in murine spleen cell cultures 2. distinguishing between spontaneous cyto toxic t cells and natural killer cells according to kinetics and target selectivity



Spontaneous cyto toxic t cells in murine spleen cell cultures 2. distinguishing between spontaneous cyto toxic t cells and natural killer cells according to kinetics and target selectivity



Immunology 50(3): 351-358



Murine cytotoxic T cells that arise spontaneously in cultures (SCTL) appear to be distinct from natural killer (NK) cells. The specificity of these 2 types of cytotoxic cell populations was compared by direct cytotoxicity and cold target inhibition tests. The SCTL population consists of an array of cytotoxic cells each of which is specific for a series of target cells. The NK cells had a more limited range of target selectivity although at least 2 types of NK effector cells were detected on the basis of specificity measurements.

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Accession: 006465740

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