Steric course of n 5 n 10 methylenetetrahydrofolate formation from glycine by the glycine cleavage system in escherichia coli

Aberhart, D.J.; Russell, D.J.

Journal of the American Chemical Society 106(17): 4907-4910

1984


ISSN/ISBN: 0002-7863
Accession: 006478431

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Abstract
The steric course of the conversion of glycine to 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate) by the glycine cleavage system in E. coli was elucidated. 2-Hre of glycine is the precursor of 11-Hre of 5,10-CH2-H4folate, and 2-Hsi of glycine is the precursor of 11-Hsi of 5,10-CH2-H4folate. The overall transformation is at least 78% stereospecific (possibly higher).