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Steroids derived from fusidic acid 3. formation of a 9 beta steroid from a delta 9 11 steroid precursor x ray crystal structure of 3 alpha acetoxy 4 alpha 8 alpha 14 beta trimethyl 18 nor 5 alpha 9 beta 13 beta androstan 17 one



Steroids derived from fusidic acid 3. formation of a 9 beta steroid from a delta 9 11 steroid precursor x ray crystal structure of 3 alpha acetoxy 4 alpha 8 alpha 14 beta trimethyl 18 nor 5 alpha 9 beta 13 beta androstan 17 one



Journal of the Chemical Society Perkin Transactions I (6): 1447-1450



The crystal and molecular structure of 3.alpha.-acetoxy-4.alpha.,8.alpha.,14.beta.-trimethyl-18-non-5.alpha.,9.beta.,13.beta.-androstan-17-one was determined by X-ray crystallography. Crystals are orthorhombic, space group P212121 with Z = 4, in a unit cell of dimensions a = 7.274(1), b = 10.041 (1), c = 28.263 (4) .ANG. The structure was solved by direct methods and refined by full-matrix least-squares calculations to R 0.043 for 1 761 observed reflections. The C (9) .beta.-configuration for the steroid is established unequivocally; rings A and C have chair conformations, ring B a twisted boat, and ring D a half-chair conformation. This compound is, unexpectedly, more stable than its C(9) .alpha.-epimer.

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