EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Stimulation of prostacyclin synthesis by thromboxane A2-like prostaglandin endoperoxide analogues in cultured vascular smooth muscle cells


Stimulation of prostacyclin synthesis by thromboxane A2-like prostaglandin endoperoxide analogues in cultured vascular smooth muscle cells



Biochemical and Biophysical Research Communications 123(1): 21-26



ISSN/ISBN: 0006-291X

PMID: 6383379

The ability of 2 chemically stable thromboxane A2-like PG endoperoxide analogs, 15S-hydroxy-9.alpha.,11.alpha.-(epoxymethano)-prosta-5Z,13E-dienoic acid and 5S-hydroxy-11.alpha.,9.alpha.-(epoxymethano)-prosta-5Z,13E-dienoic acid, to stimulate PGI2 [prostacyclin] synthesis by cultured vascular smooth muscle cells isolated from rat superior mesenteric arteries was evaluated. The aforementioned analogs, at concentrations of 0.1-10 .mu.g/ml, stimulated PGI2 synthesis by 1.5- to 3-fold over basal synthesis. Evoked PGI2 synthesis was essentially over within 2-3 min of incubation, similar to previous findings made in vascular smooth muscle cells incubated with peptide hormones, vasopressin and angiotensin II. The PG-stimulatory activity of 15S-hydroxy-9.alpha.,11.alpha.-(epoxymethano)-prosta-5Z-13E-dienoic acid appeared to be receptor-mediated inasmuch as it was completely inhibited by (.+-.)5-endo-(6'-carboxyhex-2'Z-enyl)-6-exo-{1''-[N-(phenylthiocarbamoyl)hydrazono]-ethyl}-bicyclo[2,2,1] heptane, a novel antagonist of PG endoperoxide analog-provoked smooth muscle contraction and platelet aggregation. Thromboxane A2 and/or PG endoperoxide may stimulate PGI2 synthesis in vascular smooth muscle by a direct, receptor-mediated, interaction.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006482686

Download citation: RISBibTeXText

Related references

Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle. Circulation 72(6): 1202-1207, 1985

Thromboxane/prostaglandin endoperoxide-induced hypertrophy of rat vascular smooth muscle cells is signaled by protein kinase C-dependenet increases in transforming growth factor-β. Hypertension (Dallas, Tex 1979) 28(2): 169-176, 1996

Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 267(3): 1017-1023, 1993

Thromboxane/prostaglandin endoperoxide-induced hypertrophy of rat vascular smooth muscle cells is signaled by protein kinase C-dependent increases in transforming growth factor-beta. Hypertension 28(2): 169-176, 1996

Prostaglandin endoperoxide analogues which are both thromboxane receptor antagonists and prostacyclin mimetics. British Journal of Pharmacology 87(3): 543-551, 1986

Novel prostaglandin endoperoxide analogs which block thromboxane receptors and mimic prostacyclin. British Journal of Pharmacology 86(Suppl): 643P, 1985

Stimulation of vascular smooth muscle cell prostacyclin and prostaglandin e 2 synthesis by plasma lipo proteins. American Heart Association Monograph 101: III-51, 1983

Stimulation of vascular smooth muscle cell prostacyclin and prostaglandin E2 synthesis by plasma high and low density lipoproteins. Circulation Research 54(5): 554-565, 1984

On the mechanism of induction of DNA synthesis in cultured arterial smooth muscle cells by leukotrienes. Possible role of prostaglandin endoperoxide synthase products and platelet-derived growth factor. Journal of Cell Science 98: 141-149, 1991

Prostacyclin synthesis by cultured vascular smooth muscle cells influence of growth and aging. Thrombosis and Haemostasis 46(1): 38, 1981

Role of cyclic AMP in the regulation of prostacyclin synthesis by cultured vascular smooth muscle cells. Advances in Cyclic Nucleotide and Protein Phosphorylation Research 17: 585-592, 1984

Stimulation of dna synthesis by thromboxane a 2 through its specific receptor in vascular smooth muscle cells. Nishizuka, Y , M Endo And C Tanaka (Ed ) Advances in Second Messenger And Phosphoprotein Research, Vol 24 The Biology And Medicine Of Signal Transduction; 7th International Conference on Cyclic Nucleotides, Calcium And Protein Phosphorylation, Kobe, Japan, October 8-13, 1989 Xxxiii+750p Raven Press: New York, New York, Usa Illus 714, 1990

Inhibition by prostacyclin and carbacyclins of endothelin-induced DNA synthesis in cultured vascular smooth muscle cells. Prostaglandins Leukotrienes and Essential Fatty Acids 44(4): 237-239, 1991

Aspirin: an unexpected side effect on prostacyclin synthesis in cultured vascular smooth muscle cells. Science 210(4470): 663-665, 1980

Interaction of vasopressin and angiotensin II in stimulation of prostacyclin synthesis in vascular smooth muscle cells. American Journal of Physiology 257(5 Pt 1): E617-E624, 1989