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Structure of eukaryotic chromosomes and chromatin part 1 conformational flexibility in dna structure and its implications in understanding the organization of dna in chromatin/



Structure of eukaryotic chromosomes and chromatin part 1 conformational flexibility in dna structure and its implications in understanding the organization of dna in chromatin/



Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 295-298



X-ray crystallographic studies of drug-nucleic acid crystalline complexes suggested that DNA first bends or kinks before accepting an intercalative drug or dye. This flexibility in DNA structure is made possible by altering the normal C2' endo deoxyribose sugar puckering in B DNA to a mixed sugar puckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base pairs. A kinking scheme such as this would require minimal stereochemical rearrangement and would also involve small energies. An interesting superhelical DNA structure formed by kinking DNA every 10 base pairs is discussed. This structure may be used in the organization of DNA within the nucleosome structure in chromatin.

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Structure of Eukaryotic Chromosomes and Chromatin || Conformational Flexibility in DNA Structure and Its Implications in Understanding the Organization of DNA in Chromatin. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 295-298, 1978

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