+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Structure of eukaryotic chromosomes and chromatin part 1 histone interactions histone modifications and chromatin structure



Structure of eukaryotic chromosomes and chromatin part 1 histone interactions histone modifications and chromatin structure



Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 291-294



A subunit structure for chromatin is now well established. There are 2 types of monomer subunit; the subunit containing the full DNA repeat lengths of about 200 base pairs as found in most tissues and called the nucleosome which, on further digestion, yields a well defined subnucleosome 'core' particle containing 140 base pairs of DNA. Both monomer particles are thought to contain 8 'nucleosomal' histones (H2A, H2B, H3 and H4)2. The very lysine rich histone H1 is not required for the integrity of the chromatin subunit and it is generally accepted that H1 is involved in maintaining and generating higher order chromatin structures. Neutron scatter studies of the monomer nucleosomes and core particles fully support a model in which DNA is wrapped around a core of histones. There is evidence to suggest that the next order of chromatin structure is a coil of nucleosomes. An attractive current hypothesis is that the different conformational states of chromosomes through the cell cycle are determined by postsynthetic modifications of histones. In view of the high degree of conservation of the sequences of histones it is thought highly significant that histones are subjected to modification which radically alter the nature of the modified residues. Of the different modifications so far reported, 2 reversible modifications are of considerable interest: acetylation of lysines in the nucleosomal histones and phosphorylation of serines and threonines in H1.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006496498

Download citation: RISBibTeXText


Related references

Structure of Eukaryotic Chromosomes and Chromatin || Histone Interactions, Histone Modifications and Chromatin Structure. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 291-293, 1978

Structure of eukaryotic chromosomes and chromatin part 1 reconstituted histone dna complexes. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 259-268, 1978

Structure of eukaryotic chromosomes and chromatin part 2 aspects of the regulation of histone genes. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 319-324, 1978

Histone interactions, histone modifications and chromatin structure. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 283(997): 291-293, 1978

Structure of Eukaryotic Chromosomes and Chromatin || Reconstituted Histone-DNA Complexes. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 259-268, 1978

Structure of Eukaryotic Chromosomes and Chromatin || Aspects of the Regulation of Histone Genes. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 283(997): 319-324, 1978

Structure of eukaryotic chromosomes and chromatin part 1 conformational flexibility in dna structure and its implications in understanding the organization of dna in chromatin/. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 295-298, 1978

Structure of eukaryotic chromosomes and chromatin part 1 on the structure of cellular and viral chromatin. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 274-286, 1978

Histone variants histone modifications and chromatin structure. Sarma, R H (Ed ) Biomolecular Stereodynamics, Vol 2 Meeting, Albany, N Y , Usa, April 26-29, Xiii+501p Adenine Press: Guilderland, N Y , Usa Illus P125-144, 1981

Histone conformations, histone modifications, and chromatin structure. Differentiation; Research in Biological Diversity 13(1): 37-39, 1979

Structure of eukaryotic chromosomes and chromatin part 3 chromatin transcription with mercurated nucleotides. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 379-380, 1978

Structure of eukaryotic chromosomes and chromatin part 3 organization of transcribed regions of chromatin. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 343-358, 1978

On the role of histone histone interactions in controlling chromatin structure and genetic expression. Ts'o, Paul O P (Ed ) The Molecular Biology Of The Mammalian Genetic Apparatus, Vol 1 International Symposium Pasadena, Calif , Usa, Dec , 1975 Xx+444p Illus Elsevier/Excerpta Medica/North-Holland: Amsterdam, Netherlands; Elsevier/North-Holland, Inc: New York, N Y , Usa ISBN 0-7204-0625-0: 301-322, 1977

Structure of eukaryotic chromosomes and chromatin part 4 molecular architecture of drosophila melanogaster chromatin. Philosophical Transactions of the Royal Society of London B Biological Sciences 283(997): 407-410, 1978

Histone variants and histone modifications in chromatin fractions from hetero chromatin rich peromyscus eremicus cells. Experimental Cell Research 138(2): 271-286, 1982