Studies of surface antigens on adult Schistosoma mansoni and Schistosoma haematobium
Shah, J.; Ramasamy, R.; Kinoti, G.K.
East African Medical Journal 62(11): 776-783
ISSN/ISBN: 0012-835X PMID: 3830680 Accession: 006502272
The characterisation of surface antigens on schistosomes is important for the understanding of the host-parasite relationships in schistosomiasis. The earlier characterisation of surface antigens of adult S. mansoni was extended to studying the distribution on these antigens on male and female worms and worms from different areas of Kenya. The presence of cross-reacting surface antigens on S. mansoni and S. haematobium was also investigated. The results showed that the four regular detected antigens of molecular weights of 150,000, 78,000, 45,000 and 22,000 were present on both male and female worms and worms from different areas of Kenya. The surface antigens on S. haematobium were shown to cross-react with S. mansoni. These findings are likely to be of importance when considering the development of an effective vaccine against schistosomiasis.