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Studies on acquired systemic resistance in mice after oral immunization with shigella sonnei



Studies on acquired systemic resistance in mice after oral immunization with shigella sonnei



Archivum Immunologiae et Therapiae Experimentalis 28(2): 345-356



Virulent, viable S. sonnei bacilli, introduced orally, induced resistance in mice against lethal i.v. infection with dysentery bacilli. The immunized animals survived lethal infection, and bacilli were effectively destroyed in the spleen and liver of the immunized animals. Orally induced immunity may be transferred into nonimmunized mice by means of serum and spleen cells taken on definite days after immunization of donors. Protective activity of serum appeared to be dependent on the presence of specific antibodies and was correlated with their titer. Protective activity of spleen cells occurred about 6 days after immunization of the cell donors with the bacilli. Cell suspensions, prepared from the spleens taken from donors on day 6, protected 100% of the recipients of these cells from lethal infection. Bacterial infection developing in the intestine mobilizes both local and general immunity. The mechanism of general immunity induced by orally administered dysentery bacilli is discussed.

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Accession: 006503905

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