EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Studies on acute gastric mucosal lesion due to brain damage ii. analysis of gastric mucosal prostaglandin e1 in rats with acute upper gastrointestinal mucosal lesions



Studies on acute gastric mucosal lesion due to brain damage ii. analysis of gastric mucosal prostaglandin e1 in rats with acute upper gastrointestinal mucosal lesions



Okayama Igakkai Zasshi 96(11-12): 1037-1048



Changes in gastric mucosal prostaglandin (PG) E1 in rats with acute gastric mucosal lesions caused by water immersion stress or by brain damage were studied. Rats with brain damage were prepared by injecting cyanoacrylate into the brain. PGs were extracted from gastric mucosae, and PGE1 was separated by silicic acid column chromatography and converted into PGB by alkaline treatment. PGE1 was measured by radioimmunoassay using a double antibody method with anti-PGB1 antibody. In normal rats, values of PGE1 in the gastric mucosa were 249.3 + 64.3 pg/mg protein (mean + standard deviation). In the rats which underwent water immersion stress, PGE1 values were significantly elevated (p < 0.01) above the normal values 2, 3, and 6 hours after the treatment. In the rats with brain damage, PGE1 values did not change significantly for 3 hours after the brain damage. However, 6 hours after the treatment, PGE1 values were significantly elevated (p < 0.01) above the normal values. In the rat which underwent water immersion stress, the elevation of PGE1 was inhibited by intraperitoneal administration of atropine sulfate, diazepam, hexamethonium bromide or 6-hydroxy dopamine (6-OHDA). In contrast, in the rats with brain damage, the elevation of PGE1 was significantly suppressed only by hexamethonium bromide and 6-OHDA which suppress the sympathetic nerve.

(PDF emailed within 1 workday: $29.90)

Accession: 006503947

Download citation: RISBibTeXText



Related references

Studies on acute gastric mucosal lesion due to brain damage i. endoscopic study of upper gastrointestinal lesions following cerebrovascular accidents. Okayama Igakkai Zasshi 96(11-12): 1027-1036, 1987

Experimental studies on the mechanism of onset of acute gastric mucosal lesion involved with obstructive jaundice changes of gastric mucosal local factors of acute gastric mucosal lesion in rats with obstructive jaundice and biliary drainage and the prophylactic effect of cimetidine. Medical Journal Of Hiroshima University: 31-68, 1985

Protective effects of liposome-encapsulated SOD on aspirin-induced acute gastric mucosal lesion in rats: II. Studying on gastric mucosal blood flow and permeability. Acta Academiae Medicinae Hubei 15(1): 10-12, 1994

Endoscopic studies on gastric mucosal defense mechanism part i. acute gastric mucosal lesion. Gastroenterological Endoscopy 27(12): 2699-2706, 1985

A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats. World Journal of Gastroenterology 11(9): 1324-1332, 2005

Changes in the gastric mucosal energy systems and development of acute gastric mucosal lesions stress ulcers in rats. Digestive Diseases & Sciences: 1481, 1988

A change in gastric mucosal ascorbic acid status with the formation, progression, and recovery of compound 48/80-induced acute gastric mucosal lesions in rats. Journal of Nutritional Science and Vitaminology 50(5): 371-376, 2004

A change in gastric mucosal ascorbic acid status with the formation, progression, and recovery of compound 48/80-induced acute gastric mucosal lesions in rats. Journal of Nutritional Science and Vitaminology 50(5): 371-376, 2005

Gastric mucosal blood flow and proton permeability in relation to bicarbonate secretion in acute gastric mucosal lesions induced by acid and ethanol in rats. Gastroenterology 92(5 PART 2): 1559, 1987

Role of gastric mucosal energy metabolism and lipid peroxidation in pathogenesis of acute gastric mucosal lesions induced water-immersion and restraint stress in obstructive jaundice in rats. Gastroenterology 112(4 SUPPL ): A1472, 1997

Studies on galactosyltransferase activity of gastric mucosa in rats part 2. studies on the etiology of acute gastric mucosal lesions in the rat with brain injury. Okayama Igakkai Zasshi 98(7-8): 635-644, 1986

Role of gastric mucosal blood flow and mucus after lateral hypothalamic damage in the development and delayed restoration of gastric mucosal lesions induced by taurocholic acid in rats. Gastroenterology 92(5 PART 2): 1610, 1987

Quantitative assessment of gastric mucosal bleeding in the development of acute gastric mucosal lesions in the rat and prophylactic effect of elcatonin. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 95(3): 113-119, 1990

Effect of sofalcone on acute gastric mucosal lesions induced by aspirin and ethanol in reference to the biosynthesis of gastric mucosal glycoprotein. Research Communications in Chemical Pathology and Pharmacology 54(3): 321-337, 1986

Role of endogenous gastric mucosal prostaglandins in the formation of acute gastric mucosal lesions induced by aspirin, ethanol, HCl and CH3COOH. Gastroenterologia Japonica 22(3): 273-279, 1987