Studies on alpha fetoprotein 3. with particular reference to alpha feto protein producing cells in the early stage of the so called 2nd response of experimental hepato carcinogenesis in azo dye fed rats

Kamimura, N.

Nichidai Igaku Zasshi 38(3): 595-612


ISSN/ISBN: 0029-0424
Accession: 006504147

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Oval cells in the rat represented the main AFP[.alpha.-fetoprotein]-producing cells in the 1st response of experimental hepatocarcinogenesis, and hepatoma cells represented the main cells producing AFP in the 2nd response. The relative distribution in each lobe was evaluated and the mutual relations between the former and latter cells were studied, in parallel to observing the quantitative changes in serum AFP levels for 20 wk. Previously undetected AFP-producing cells were observed in the early stage of the 2nd response by the direct immunofluorescent technique. There were roughly patterns of change in AFP levels. Oval cells and hepatoma cells were densely distributed in the No. 3, 4 and 5 lobes. The oval cell apparently represented a bearing body of hepatoma cells. The number of AFP-producing cells in the early stage of the 2nd response was very few. The AFP-producing cells seen in the early stage of the 2nd response were small, and closely resembled the so-called small hepatic cells.