Studies on anti helminthic effects of praziquantel against parasites in animals 2. the efficacy of praziquantel against various larval cestodes in laboratory animals

Sakamoto, T.; Kono, I.; Yasuda, N.; Yamamoto, Y.; Nakagawa, H.

Bulletin of the Faculty of Agriculture, Kagoshima University 30: 123-130

1980


ISSN/ISBN: 0453-0845
Accession: 006504363

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Abstract
The cestocidal effect of praziquantel was investigated on 3 spp of larval cestodes. Injection i.m. of praziquantel at a dose rate of 100 mg/kg body weight (b.w.) 3 times daily for 10 alternate days killed all strobilocerci of larval Hydatigera taeniaeformis in rats. The injection of a single daily dose of 200 mg/kg b.w. for 10 successive days caused degeneration and death of the majority of strobilocerci. The drug given at 250 mg/kg b.w. daily for successive days inhibited growth and multiplication of tetrathyridia of Mesocestoides corti in the liver and in the abdominal cavity of mice. Mice experimentally infected with cysts of Echinococcus multilocularis in the liver were treated 3 times daily with 250 mg/kg b.w. of praziquantel for 5 and 10 alternate days. In a further trial, 500 mg/kg b.w. of praziquantel was given once a day for 10 consecutive days. Although low efficacy was shown by these regimens on echinococcal tissue in the liver, some degenerative changes in the echinococcal tissue in the abdominal cavity were established histologically.