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Chapter 6,505

Studies on beta pyridyl carbinol as a precursor of nad

Kizu, A.; Nakamura, T.; Kato, S.; Sawada, K.; Ijichi, H.; Kuriyama, K.

Japanese Journal of Pharmacology 27(6): 817-822

1977


ISSN/ISBN: 0021-5198
Accession: 006504846

The major part of orally administered .beta.-pyridylcarbinol was converted to nicotinic acid [a potent vasodilator] in the gastrointestinal tract that administered i.p. was partially converted to nicotinic acid in the mouse liver. The conversion of this compound to nicotinic acid in both the gastrointestinal tract and liver involved enzymatic processes. The converted nicotinic acid from .beta.-pyridylcarbinol may play a dominant role in the biological actions of .beta.-pyridylcarbinol and possibly involves in the synthesis of NAD via Preiss-Handler's pathway.

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