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Studies on radio calcium metabolism in pigs which suffer from a hereditary form of rickets pseudo vitamin d deficiency rickets



Studies on radio calcium metabolism in pigs which suffer from a hereditary form of rickets pseudo vitamin d deficiency rickets



International Journal of Applied Radiation & Isotopes 34(5): 817-822



Intestinal Ca absorption and calcium kinetics of plasma were studied in pigs which suffer from pseudovitamin D deficiency rickets using 45Ca. 200-250 .mu.Ci 45CaCl2 were administered either orally or i.v. on 2 consecutive days. Serial plasma samples (30-40) were taken during the following 24 h. The radioactivity with time curves following an i.v. injection of 45Ca were fitted to different exponential equations which contained an increasing number of exponential components. Goodness of fit of the individual values with the theoretical curves improved from 100-9.6 when a 3rd exponential component was included into a 2-exponential equation. Computerized approximation of the experimental data could not greatly be improved further when the number of exponential components included in the equation was greater than three. Plasma Ca kinetics during 24 h could adequately be described by a 3 compartment model. Coefficients of intestinal Ca absorption have also been obtained from the same animals after an oral administration of radiocalcium. When the animals were treated with physiological doses (5 .mu.g/day) of a Ca metabolite (1,25(OH)2D3) rate constants of plasma Ca turnover increased markedly as well as coefficients of intestinal Ca absorption. The kinetic parameters of calcium metabolism, which were obtained in these studies during 24 h sampling, may be used as sensitive indices to describe possible changes in Ca hemostasis.

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