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Studies on supravital observation of basophils in bronchial asthma in immunological reaction part 2 morphological changes of basophils upon addition of anti immuno globulin



Studies on supravital observation of basophils in bronchial asthma in immunological reaction part 2 morphological changes of basophils upon addition of anti immuno globulin



Okayama Igakkai Zasshi 87(11-12): 963-971



Morphologic changes (in vitro) of peripheral blood basophils of patients with atopic bronchial asthma (serum IgE [immunoglobulin E] more than 1000 U[units]/ml) and intractable bronchial asthma (serum IgE less than 100 u/ml) were studied by addition of anti-IgE or anti-IgG. In supravital observation using differential-inteference microscopy, basophils, when exposed to anti-immunoglobulin, moved rapidly and changed morphologically to a pear-shaped and next to a hand-shape. Degranulation occurred from the tip of the cytoplasmic processes by exocytosis. Using phase contrast microscopy, intracellular changes of granules and vacuolation were clearly observed, but ejection of granules were not observed using this method.

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