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Studies on the effects of furazolidone and p rosaniline on the kinetoplast of trypanosoma gambiense in mice



Studies on the effects of furazolidone and p rosaniline on the kinetoplast of trypanosoma gambiense in mice



Biken Journal 19(2): 63-69



p-Rosaniline-sensitive and -resistant strains of T. gambiense were separately passaged in mice treated with furazolidone. After 10 serial passages in mice, the trypanosomes were resistant to furazolidone when tested in mice. The rate of appearance of AK [kinetoplast devoid] forms after injection of furazolidone into mice infected with a clone obtained from the p-rosaniline resistant strain by repeated treatment with furazolidone (WRF) was lower than that in mice infected with a clone obtained from the p-rosaniline sensitive strain by the same treatment with furazolidone (WSF). WSF was resistant to p-rosaniline, although it was not exposed to it. There is apparently an interaction between the actions of furazolidone and p-rosaniline on the kinetoplast. The existence of this interaction was supported by EM observations on the kinetoplasts of trypanosomes after the injection with p-rosaniline and furazolidone into mice infected with the p-rosaniline resistant clones, WSF and WRF.

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Accession: 006516061

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PMID: 985375



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