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Studies on the etiology and therapy of sjogrens syndrome 2. effects of steroid hormone on patients with sjogrens syndrome without associated diseases



Studies on the etiology and therapy of sjogrens syndrome 2. effects of steroid hormone on patients with sjogrens syndrome without associated diseases



Okayama Igakkai Zasshi 94(1-2): 35-44



The effect of prednisolone (PSL) on clinical symptoms and laboratory parameters was studied in 19 patients with Sjogren's syndrome (SjS) without associated diseases (SjS alone). The mean initial dose of PSL was 11.7 .+-. 13.0 mg/day, and the mean maintenance dose was 6.1 .+-. 3.9 mg/day. The mean duration of the treatment was 25.2 .+-. 14.1 mo. Fever, polyarthralgia, elevated erythrocyte sedimentation rate and hypergammagloblinemia were improved by the PSL treatment. No effect of PSL on the ocular and oral sicca symptoms including parotoid enlargements, function of the exocrine glands and sialographical findings of parotid glands was observed. Neither Raynaud's phenomenon nor various autoantibodies detected in patients' sera were affected by this treatment.

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