Studies on the formation of lipophilic derivatives of the chemical carcinogen 7 12 di methyl benz a anthracene in vivo

Khanduja, K.L.

Bulletin Postgraduate Institute of Medical Education and Research Chandigarh 12(3): 144-149


Accession: 006516848

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Maximum radioactivity concentration in the liver, spleen, kidney and blood was observed after 5 min of i.v. administration of DMBA-3H [tritiated 7,12-dimethylbenz(a)anthracene] to rats. In the mammary gland accumulation of DMBA-3H continued up to 90 min. The amount of unmetabolized carcinogen in the liver, spleen, kidney and blood after 4 h was almost negligible but in the mammary gland a significant concentration of DMBA-3H was retained up to 24 h. Composition of the lipophilic derivatives of DMBA was studied with Sephadex LH-20 filtration and TLC.