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Studies on the migration of basophilic leukocytes at the sites of allergic reactions part 2 appearance of basophilic leukocytes at the sites of immediate type skin reactions



Studies on the migration of basophilic leukocytes at the sites of allergic reactions part 2 appearance of basophilic leukocytes at the sites of immediate type skin reactions



Okayama Igakkai Zasshi 89(11-12): 1461-1474



Vesicular exudate was produced by the application of Unguentum Vesicans on the skin which was treated with various allergenic extracts. The exudate was examined for the presence of basophils and eosinophils in 134 patients with bronchial asthma. Larger numbers of total white cells in the vesicle were seen at the sites of the skin test than at the untreated skin sites. A slightly larger number of basophils and eosinophils was found in the vesicular fluid at the sites of positive immediate-type skin reactions, than in the sites of negative reactions to an allergen. Basophils appeared in relatively higher rates in the fluid of positive reaction to Candida or ragweed than to house dust. There were more basophils and eosinophils in the vesicular fluid with positive reactions using higher concentrations of Candida or house dust extract than when using lower concentrations. Both cells increased in number at the skin reaction site at the endpoint concentration of house dust. There was a relationship between basophil numbers in peripheral blood and those in the skin vesicles. When more than 65 basophils were found per mm3 of peripheral blood, there was greater basophil migration to the skin lesions than in cases where less than 65 basophils/mm3 were found. The same was found for eosinophils. No correlation between serum Ig[immunoglobulin]E level and intravesicular appearance rate of basophils was observed. Among the patients with occupational asthma induced by inhalation of timber dust of Chinese quince or rosewood and by inhalation of buckwheat, basophils and eosinophils appeared in large numbers at the sites of positive immediate skin reactions to the special allergens. Basophils and eosinophils can easily migrate from the blood vessels into extravascular tissues at sites of allergic reactions, especially in reaginic hypersensitivity. Basophils and eosinophils or either cell type alone appeared in large numbers at sites of positive immediate reactions if allergens were specific in individual cases. The skin vesicle technique described above may be of great use for detecting allergens and evaluating allergic disease states.

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Accession: 006519281

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