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Studies on the super oxide generating system super oxide dis mutase and lipo per oxide in rheumatoid arthritis 2. trial of cepharanthine bis coclaurine alkaloid intra articular injection in the treatment of rheumatoid arthritis including influence of cepharanthine bis coclaurine alkaloid on lipo per oxide level synovial fluid super oxide dis mutase activity and synovial fluid leukocyte super oxide dis mutase activity



Studies on the super oxide generating system super oxide dis mutase and lipo per oxide in rheumatoid arthritis 2. trial of cepharanthine bis coclaurine alkaloid intra articular injection in the treatment of rheumatoid arthritis including influence of cepharanthine bis coclaurine alkaloid on lipo per oxide level synovial fluid super oxide dis mutase activity and synovial fluid leukocyte super oxide dis mutase activity



Okayama Igakkai Zasshi 92(11-12): 1205-1216



Cepharanthine was administered intraarticularly [i.a.a.] to rheumatoid arthritis (RA) patients who showed no beneficial response to i.a.a. RA treatment. Joint symptoms, volume, leukocyte counts, relative viscosity, lysosomal enzyme activity, C-reactive protein concentration, lipoperoxide level, and superoxide dismutase (SOD) activity of synovial fluid and of synovial fluid leukocytes were tested before and after i.a.a. injection of cepharanthine. The therapeutic effects on hydroarthrosis were also investigated. The RA patients were divided into the following 3 groups: group 1, patients who received only cepharanthine i.a.a. injection; group 2, patients who received cepharanthine i.a.a. injection and corticosteroid i.a.a. injection .apprx. 1 wk later; group 3, patients who received simultaneous i.a.a. injection of cepharanthine and corticosteroid. The decrease frequency of knee puncture and the reduction of synovial fluid volume were prominent in 5 of 9 (55.5%) cases in Group 1, 5 of 5 (100%) cases in group 2, and 4 of 4 (100%) cases in group 3. Cepharanthine had no effect on leukocyte count, relative viscosity, lysosomal enzyme activity or C-reactive protein concentration. Cepharanthine had no effect on lipoperoxide level, synovial fluid SOD activity or synovial fluid leukocyte SOD activity. All 4 cases who had a cepharanthine 20 or 30 mg injection experienced a post-injection flare-up-like phenomenon. Three of 14 (21.4%) cases who had cepharanthine 10 mg experienced a slight post-injection flare-up-like phenomenon. Post-injection flare-up-like phenomena did not appear in group 3. Simultaneous i.a.a. injection of cepharanthine 10 mg and corticosteroid was the most effective method. Simultaneous i.a.a. injection of cepharanthine 10 mg and corticosteroid evidently was a useful measure for the treatment of the so-called wet type of RA.

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