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Studies on the syngeneic mixed lymphocyte reaction 1. the ontogeny of the syngeneic mixed lymphocyte reaction in mice



Studies on the syngeneic mixed lymphocyte reaction 1. the ontogeny of the syngeneic mixed lymphocyte reaction in mice



Immunology 46(4): 727-736



The syngeneic mixed lymphocyte reaction (SMLR) is the proliferative response of T lymphocytes cultured with syngeneic non-T lymphocytes. The ontogenic development of the SMLR was studied in BALB/c mice. The SMLR is not demonstrable in BALB/c mice less than 3 wk old. The SMLR attains an adult level of activity at 4 wk of age. Splenic T cells from mice less than 3 wk old do not respond and splenic non-T cells do not stimulate an SMLR. T-cell preparations acquire the capacity to respond in the SMLR between 2-3 wk of age and non-T cells acquire the capacity to stimulate in SMLR between 3-4 wk old. Spleen cells from 1 wk old mice suppress the adult SMLR. Suppressor activity was eliminated by depleting either Thy-1.2 positive cells or adherent cells. When suppressor activity was eliminated, spleen cells from 1 wk old donors were capable of stimulating syngeneic T cells. Spleen cells from 1 wk old nude BALB/c mice do not suppress the SMLR and stimulate syngeneic T cells normally. Apparently, the impaired SMLR in very young mice is, at least in part, due to cell-mediated suppression of the SMLR.

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Accession: 006522259

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PMID: 6213553



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