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Studies on the syngeneic mixed lymphocyte reaction 1. the ontogeny of the syngeneic mixed lymphocyte reaction in mice






Immunology 46(4): 727-736

Studies on the syngeneic mixed lymphocyte reaction 1. the ontogeny of the syngeneic mixed lymphocyte reaction in mice

The syngeneic mixed lymphocyte reaction (SMLR) is the proliferative response of T lymphocytes cultured with syngeneic non-T lymphocytes. The ontogenic development of the SMLR was studied in BALB/c mice. The SMLR is not demonstrable in BALB/c mice less than 3 wk old. The SMLR attains an adult level of activity at 4 wk of age. Splenic T cells from mice less than 3 wk old do not respond and splenic non-T cells do not stimulate an SMLR. T-cell preparations acquire the capacity to respond in the SMLR between 2-3 wk of age and non-T cells acquire the capacity to stimulate in SMLR between 3-4 wk old. Spleen cells from 1 wk old mice suppress the adult SMLR. Suppressor activity was eliminated by depleting either Thy-1.2 positive cells or adherent cells. When suppressor activity was eliminated, spleen cells from 1 wk old donors were capable of stimulating syngeneic T cells. Spleen cells from 1 wk old nude BALB/c mice do not suppress the SMLR and stimulate syngeneic T cells normally. Apparently, the impaired SMLR in very young mice is, at least in part, due to cell-mediated suppression of the SMLR.

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Accession: 006522259

PMID: 6213553



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