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Studies on the syntheses of analgesics part 7 syntheses of 1 2 3 4 tetra hydro 4 4 dimethyl iso quinoline derivatives






Yakugaku Zasshi 96(4): 401-406

Studies on the syntheses of analgesics part 7 syntheses of 1 2 3 4 tetra hydro 4 4 dimethyl iso quinoline derivatives

1,2,3,4-Tetrahydro-4,4-dimethylisoquinoline derivatives were synthesized via the Bischler-Napieralski reaction of N-formyl-2-(3-methoxyphenyl)-2-methylpropylamine; the cyclization of 2-(2-chloromethyl-5-methoxyphenyl)-2-methylpropyl chloride and the Beckmann rearrangement reaction of 5-methoxy-3,3-dimethyl-1-indanone oxime. Some of the compounds have an analgesic activity in mice.

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Accession: 006522266



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