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Studies on the synthesis of dihydrofolate reductase inhibitor 5 substituted phenylthioseleno 2 4 diaminopyrimidines and their inhibitory activity to lactobacillus casei and chicken liver dhfr



Studies on the synthesis of dihydrofolate reductase inhibitor 5 substituted phenylthioseleno 2 4 diaminopyrimidines and their inhibitory activity to lactobacillus casei and chicken liver dhfr



Yaoxue Xuebao 22(2): 136-140



According to the principle of isosterism the -CH2-group of 5-(substituted benzyl)-2,4-diaminopyrimidine was modified by-S-and-Se-and some 5-(substituted phenyl)thio-2,4-diaminopyrimidines and 5-(substituted phenyl)seleno-2,4-diaminopyrimidines were synthesized. Their inhibitory activities on L. casei and chicken liver dihydrofolate reductase were determined. Preliminary data showed that the inhibitory activities of these compounds were less than those of the corresponding 5-(substituted benzyl)-2, 4-diaminopyrimidines. Their selectivities are also decreased.

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Related references

Studies on the synthesis of dihydrofolate reductase inhibitor, 5-(substituted phenyl)-thio(seleno)-2, 4-diaminopyrimidines and their inhibitory activity on L. casei and chicken liver DHFR. Yao Xue Xue Bao 22(2): 136-140, 1987

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