+ Translate

Studies on the synthesis of mitomycins 4. elucidation of the configuration of mitosane derivatives

, : Studies on the synthesis of mitomycins 4. elucidation of the configuration of mitosane derivatives. Liebigs Annalen der Chemie (7): 1437-1447

The configurations of the mitosane derivatives described in the previous communications were established by spectroscopic investigations and X-ray analysis of rac-1e.

(PDF 0-2 workdays service)

Accession: 006522355

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Flitsch, W.; Russkamp, P., 1985: Studies on the synthesis of mitomycins 1. synthesis of the mitosane skeleton by intramolecular condensation and reformatsky reaction. Benzopyrrolizinones 10 were obtained from the succinimido esters 6b, c by intramolecular condensation in moderate yields. A stereoselective Reformatsky reaction of the bromo esters 7 was accelerated by ultrasonication to give the 9a-functionalized...

Flitsch, W.; Russkamp, P., 1985: Studies on the synthesis of mitomycins 3. functionalizations of mitosene derivatives. The introduction of a (carbamoyloxy)methyl function into position 9 of the benzopyrrolizinones 1 is described together with a stereoselective functionalisation of the 9a position. Possibilities to introduce the quinone group are presented.

Matsui, M.; Yamada, Y.; Uzu, K.; Hirata, T., 1968: Studies on mitomycins. 3. The synthesis and properties of mitomycin derivatives. Journal of Antibiotics 21(3): 189-198

Kametani, T.; Takahashi, K.; Ihara, M.; Fukumoto, K., 1979: The syntheses of hetero cyclic compounds 777. a synthetic approach to seco mitosane type of compound related to mitomycins. 1,2,3,4,5,6-Hexahydro-5,5,8-trimethoxy-9-methyl-1-benzazocine-7,10-dione was synthesized from 2,3-dihydro-7-methoxy-6-methyl-1H-pyrrolo[1,2-a]indole-5,8-dione. The key intermediate, 7,10-diacetoxy-5-trifluoroacetoxy-1-trifluoroacetyl-1,2,3,4,5,6-h...

Krylova R.G.; Shashkov A.S.; Usov A.I., 1989: Synthesis of 3 bromo 3 deoxy derivatives with allo configuration from corresponding methyl beta cellobioside and cellulose chlorosulfates and their structure elucidation using carbon 13 nmr spectra. Reaction of 6-O-trityl-cellulose 2,3-bis-chlorosulfate with tetra-n-butylammonium bromide afforded substituted cellulose derivatives with 3-bromo-3-deoxy-D-allopyranose residues and degree of substitution up to 0.74. Similarly, methyl 3-bromo-3-de...

Yoshida K.; Nakajima S.; Ohnuma T.; Shibasaki M.; Ban Y., 1987: Synthesis of the highly oxygenated benzazocine derivatives toward mitomycins. Journal of Pharmaceutical Sciences 76(11): S151

Kanda, Y.; Arai, H.; Ashizawa, T.; Morimoto, M.; Kasai, M., 1992: New potent mitomycin derivatives: synthesis and antitumor activity of 7,7-(ethylenedioxy)mitomycins. A series of 6,7-dihydro-7,7-(ethylenedioxy)mitomycins was synthesized and evaluated for antitumor and anticellular activities. These compounds were prepared by basic treatment of 7-methoxymitomycins with ethylene glycol, and were structurally nove...

Hirayama, N.; Shirahata, K., 1987: Structural studies of mitomycins i. absolute configurations of mitomycins a and b. The absolute configurations of mitomycins A and B were determined by the Bijvoet difference method. (A) 1-N-(p-Bromobenzoyl)mitomycin A, C23H22BrN3O7, Mr = 520.35, orthorhombic, P21212, a = 20.277 (1), b = 27.320 (4), c = 8.348 (4) .ANG., V = 4624...

Anonymous, 1964: Studies on mitomycins, carcinostatic antibiotics I Derivatives and acid hydrolysis of mitomycin A and C

Flitsch, W.; Russkamp, P.; Langer, W., 1985: Studies on the synthesis of mitomycins 2. synthesis of the mitosene skeleton by intramolecular wittig olefination. Efficient methods for the preparation of benzopyrrolizine derivatives using intramolecular Wittig olefination as cyclization reaction are presented. Subsequent Vilsmeier formylation results in the formation of the mitosene skeleton.