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Studies on the variation of japanese b encephalitis virus part 6 the changes in virulence and immunity after passaging sub cutaneously in suckling mice


Weishengwu Xuebao 15(2): 133-138
Studies on the variation of japanese b encephalitis virus part 6 the changes in virulence and immunity after passaging sub cutaneously in suckling mice
A method for inducing the JBE [Japanese B encephalitis] virus variation is reported. JBE virus strain SA4CEC (slightly attenuated and rendered nonimmunogenic by subpassaging in suspended chick embryo fibroblasts) virulence was further reduced and its immunogenicity was enhanced after subpassage continuously in the subcutaneous tissues of suckling mice. The virus was repeatedly purified by plaque-selection on monolayer chick embryo fibroblasts. A new mutant, intracerebrally avirulent to mice and possessing immunogenicity, was obtained.


Accession: 006522926



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