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Studies on the vascular and hematological changes induced by ellagic acid in rats

Studies on the vascular and hematological changes induced by ellagic acid in rats

Agents & Actions 22(3-4): 270-279

We compared the major changes induced by ellagic acid (EA), a Hageman factor activator, in normal rats and in the kininogen-deficient Brown Norway rats. In normal rats, large doses of EA induced a congestion of lymph nodes, spleen and liver, a prolongation of activated partial thromboplastin time, the consumption of prekallikrein, high molecular weight kininogen and fibrinogen, as well as the stimulation of platelets with their accumulation in lungs, liver and spleen. A systemic hypotension of long duration was also observed. The fibrinogen consumption, the thrombocytopenia and the lengthening of inactivated partial thromboplastin time were dose-dependent. In kininogen-deficient rats, EA induced only a minimal congestion of lymphoid tissues. It is concluded that the vascular changes induced by blood coagulation with ellagic acid resulted mainly from kinin formation.

Accession: 006522935

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PMID: 3445821

DOI: 10.1007/bf02009056

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