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Study of effect of the daytime anti histaminic mebhydrolin on motor reaction time and mental processing time



Study of effect of the daytime anti histaminic mebhydrolin on motor reaction time and mental processing time



Clinical Therapeutics 1(3): 219-227



The effect of the antihistaminic agent mebhydrolin (50 mg) was tested in a double-blind study in 10 male subects with an average age of 23 yr. Tests lasting 45 min were carried out 2 h and 4 h after tablet ingestion. Purely motor reaction times to strictly randomized, stochastic acoustic stimuli and assimilation times for visual patterns (3-letter arrays) were studied. Number of reading errors was recorded. Pulse rate and integral pulse variability served as physiological parameters for assessment of stress. A double-blind test lasting 40 min revealed no highly significant effect of the test preparation (active ingredient: 50 mg mebhydrolin) -either subjectively or objectively-on work capacity in the area of motor reactions and of the assimilation of optical patterns by man, either 2 h or 4 h after tablet ingestion. Only in the 1st phase of the test, 2 h after ingestion, was mental processing time (RT2) prolonged significantly (5% level). In the area of mental activities composed mainly of the above-mentioned components, no effect on the performance is to be expected 4 h after administration of the drug, even though this is the time at which the peak plasma level is recorded. In the 1st test phase, 2 h after ingestion of tablets, a highly significant increase of pulse rate was observed after mebhydrolin. In the 2nd test phase the drug had no significant effect on pulse rate. The reverse was also the same for integral pulse variability. No correlation was found between circulatory data and measured psychophysical performance.

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