Study of human bone marrow derived and thymus derived lymphocytes with heterologous anti sera 5. common antigens shared by thymus derived and bone marrow derived cells

Brochier, J.; Bouveret, E.; Vuvan, H.; Andary, M.; Clot, J.

Thymus 1(6): 311-318

1980


ISSN/ISBN: 0165-6090
Accession: 006525862

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Abstract
Preparation of an antiserum specific for human T . Further absorption on circulating T cells of the antiserum which still reacted with CLL cells removed all anti-T and -B activity, showing that these non-HTLA antigens were common to some T and B cells. B cells bearing these antigens were present in about 50% of CLL and 5-10% of tonsil lymphocytes; 10-20% of tonsil B cells carried them, whereas an average of 3.8% of blood lymphocytes bore these antigens in exclusion from specific T or B cell characteristics. These antigens were present on cells from certain acute lymphocytic leukemias (ALL). They can be characteristic of early stages of differentiation of T and B lymphocytes. They are absent from mature B cells, but still remain in at least a subpopulation of circulating T lymphocytes. Whether or not detection of these antigens can help the diagnosis and prognosis of lymphoproliferative diseases is under investigation.