EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Subacute and chronic myelo monocytic leukemia in children juvenile chronic myelo monocytic leukemia clinical and hematologic observations and identification of prognostic factors






Cancer 54(4): 675-686

Subacute and chronic myelo monocytic leukemia in children juvenile chronic myelo monocytic leukemia clinical and hematologic observations and identification of prognostic factors

The clinical and hematologic characteristics of 38 children with subacute and chronic myelomonocytic leukemia (S and CMMOL) are described, and the prognostic significance of these characteristics as recorded at diagnosis is reported. The common and distinctive feature of these children was the excessive proliferation of cells of neutrophilic and monocytic series. The decrease predominated in younger children, 95% were younger than 4 yr, and boys were more affected than girls (22/16). The onset of the disease was heralded most often by acute or subacute symptoms. Splenomegaly was the most common physical finding at diagnosis. Leukocytosis was usually under 100 .times. 109/l. Monocytosis and granulocytosis were often associated with normoblastosis, and, in some cases, with moderate blastosis (.ltoreq. 30%). Severe anemia and marked thrombocytopenia were found in about 1/3 of patients, increased fetal Hb levels in 53%, and increased .gamma.-globulin levels in 50% of cases. The Philadelphia chromosome was absent in all blood and marrow cell karyotypes. Thirty-three of 38 patients were treated with moderate or intensive chemotherapy; treatment never resulted in a complete remission. Terminal acute leukemia occurred in 11 cases. Of the 38 patients, 29 have died (median survival time, 16 mo.). Initial characteristics predicting a short survival included: older age (.gtoreq. 2 yr), hepatomegaly, thrombocytopenia, high counts of blasts and normoblasts in peripheral blood. When survival was plotted on a semilogarithmic scale, a change in death rate was evident at the 2nd yr of survival, suggesting that there may be 2 subgroups of patients with myelomonocytic picture, with different rates of mortality. A stepwise discriminant-function analysis was performed in an attempt to distinguish between those children who lived .ltoreq. 2 yr and those who lived longer. Nearly all patients could be classified as a short-survivor or longer-survivor on the basis of age and platelet, blast and normoblast counts in peripheral blood. This discriminant function may be used for the estimation of prognosis and, accordingly, for the selection of the appropriate therapy of new cases.

(PDF 0-2 workdays service: $29.90)

Accession: 006533028



Related references

Subacute and chronic myelo monocytic leukemia in children juvenile chronic myelo monocytic leukemia survival and prognostic factors. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 22: 402, 1981

Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. Cancer 54(4): 675-686, 1984

Subacute and chronic myelo monocytic leukemia a distinct hematological entity. British Journal of Haematology 32(1): 1-7, 1976

Stimulating capacity of leukemia cells from acute nonlymphocytic leukemia chronic myelogenous leukemia blastic crisis of chronic myelogenous leukemia and chronic myelo monocytic leukemia in allogeneic 1 way mixed lymphocyte tumor cell reaction. Acta Haematologica Japonica 43(5): 796-804, 1980

Prognostic relevance of thymidine kinase in chronic myelo-monocytic leukemia. Leukemia Research 23(SUPPL 1): S57, April, 1999

Subacute myelo-monocytic leukemia. Cyto- and biochemical study of granulocytic and monocytic lines. La Semaine des Hopitaux 48(27): 1965-1970, 1972

Clinical and cyto genetic studies in chronic myelo monocytic leukemia. British Journal of Haematology 22(6): 773-782, 1972

Immunological characterization of normal and leukemia associated antigens of acute myelo monocytic leukemia and chronic myelogenous leukemia in blast crisis. Cancer Research 38(3): 716-722, 1978

Characterization of the early and late stages of myelo monocytic leukemia induced by friend helper independent virus isolation and induction of friend myelo monocytic leukemic cell lines. Journal of Cellular Physiology 117(3): 283-289, 1983

Chronic myelo monocytic leukemia. Problemy Gematologii i Perelivaniya Krovi 19(1): 40-45, 1974