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Substance p enhancement of passive avoidance and active avoidance conditioning in mice

Substance p enhancement of passive avoidance and active avoidance conditioning in mice

Pharmacology Biochemistry & Behavior 19(4): 655-662

In a series of 7 experiments the effects of peripherally administered substance P [SP] on passive and active avoidance conditioning in mice of 2 genotypes were explored. The peripheral post-trial administration of SP significantly enhanced the retention of a single-trial passive avoidance task. This effect was dose dependent; 1 ng/g of SP enhanced the retention of this habit; higher and lower doses were either less effective or ineffective. In heterogeneous strain (HS) mice, SP administered before training on an active avoidance task did not alter the rate at which these animals learned this habit. Animals that were trained with SP were significantly more resistant to extinction than were animals that were injected with vehicle. C57Bl/6J mice that were treated with SP immediately after active avoidance training were more resistant to extinction than were mice that were given control injections. The enhancement of retention of the passive avoidance habit with SP was reversed in animals that were pretreated with naltrexone. SP enhancement of the retention of the passive avoidance habit and its reversal with naltrexone was observed in both sham operated and adrenalectomized mice.

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Accession: 006535500

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