Sulfated and nonsulfated glyco proteins in human gastric juice in atrophic gastritis associated with rheumatoid arthritis
Sarosiek, J.; Badurski, J.
Polskie Archiwum Medycyny Wewnetrznej 60(6): 525-533
After ruling out gastric and duodenal ulcers, 46 patients with rheumatoid arthritis (r.a.) were divided into 4 groups depending on acid secretion after histamine. Group I was comprised of patients in whom the mean secretion was 14.8, group II-18.6, group III-3.1, group IV-O meq/h in maximum acid output. SGP (sulfated glycoproteins), NSGP (nonsulfated glycoproteins), fucose and sialic acid (NANA) were determined in whole gastric juice and in the juice fractions containing mucoprotein and mucoprotease. Acid secretion paralleled the decreased secretion of mucoprotein components, while there were no changes in mucoprotease. The 1st sign indicating possible development of atrophic gastritis was a decrease of the concentration and secretion of NANA in mucoprotein, a product of parietal cells. This change was observed in patients with normal acid secretion. Lack of changes in all the patients concentration of sialomucins in whole gastric juice was a result of reduced secretion by parietal cells and increased secretion by goblet cells appearing in areas of intestinal epithelium metaplasia. Determination of NANA in the mucoprotein may be the most sensitive approach of the known biochemical indicators of beginning atrophic gastritis. An unequivocal explaination of the observed fall of SGP secretion with progressive impairment of acid secretion after histamine stimulation could not be found.