+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Suppression of natural and activated human antitumour cytotoxicity by human seminal plasma

Suppression of natural and activated human antitumour cytotoxicity by human seminal plasma

Clinical and Experimental Immunology 63(3): 687-695

ISSN/ISBN: 0009-9104

PMID: 2423280

The influence of human seminal plasma (SP) and whole semen (S) on the expression of natural cytotoxicity by human peripheral blood mononuclear cells (PBMNC) was examined. Marked suppression of natural cytotoxicity against K562 targets was observed when effectors were pre-treated for 1 h with SP or S diluted up to 1:400. Abrogation of cytolytic activity by SP was not the result of direct lymphocytoxicity, although a reduction of approximately 50% in the number of target binding cells was observed. In addition, the cytotoxicity of interferon (.alpha.-IFN, .beta.-IFN, .gamma.-IFN) and interleukin 2 (IL-2) activated human PBMNC was suppressed by components present in human SP, although IL-2 activated human PBMC were relatively resistant to suppression compared with other effector (spontaneous or activated) populations. Following 1 h exposure to SP, PBMNC failed to recover more than 25% of their initial cytotoxic potential upon further in vitro incubation (18 h) in the absence of SP. However, both interferon and IL-2 caused an increase in the cytotoxicity of these populations, in some instances to the level obtained with control, IFN or IL-2 activated PBMNC. The biological significance of SP as an inhibitor of immune function under experimentally defined conditions is discussed in relation to its possible role in vivo.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 006544751

Download citation: RISBibTeXText

Related references

Immunosuppression by human seminal plasma as evaluated by effect on natural killer cell cytotoxicity. Indian Journal of Medical Research 96: 153-158, 1992

Variable inhibition of natural killer and fc receptor associated cytotoxicity adcc by human seminal plasma. American Journal of Reproductive Immunology 22(3-4): 99-100, 1990

Suppression of tumor-associated immunity by human seminal plasma and its possible role in the natural history of prostatic cancer. European Urology 6(4): 225-228, 1980

Suppression of the lytic activity of natural killer cells by human seminal plasma a real biological phenomenon. Medical Science Research 18(16): 637-638, 1990

Suppression of natural killer cell activity by human seminal plasma in vitro: identification of 19-OH-PGE as the suppressor factor. Journal of Immunology 136(8): 2862-2867, 1986

Inhibition of human antibody-dependent cellular cytotoxicity, cell-mediated cytotoxicity, and natural killing by a xenogeneic antiserum prepared against "activated" alloimmune human lymphocytes. Journal of Immunology 128(3): 1246-1251, 1982

Role of NKG2D, DNAM-1 and natural cytotoxicity receptors in cytotoxicity toward rhabdomyosarcoma cell lines mediated by resting and IL-15-activated human natural killer cells. Cancer Immunology Immunotherapy: Cii 64(5): 573-583, 2015

Synergistic action of a plant rhamnogalacturonan enhancing antitumor cytotoxicity of human natural killer and lymphokine-activated killer cells: chemical specificity of target cell recognition. Cancer Research 50(12): 3646-3651, 1990

In vitro studies in reproductive immunology. 1. Suppression of cell-mediated immune response by human spermatozoa and fractions isolated from human seminal plasma. Clinical Immunology and Immunopathology 9(3): 318-326, 1978

Suppression of antitumor lymphocyte mediated cytotoxicity by human chorionic gonadotropins. Journal of Urology 115(1): 95-98, 1976

Physico-chemical & antigenic characterization of human seminal plasma proteins: gamma globulins of human seminal plasma. Indian Journal of Biochemistry 3(3): 208-210, 1966

Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma. Journal of Virology 93(6), 2019

Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells. Cancer Research 59(20): 5102-5105, 1999

Suppression/stimulation of chemiluminescence by human seminal plasma. Clinica Chimica Acta; International Journal of Clinical Chemistry 200(1): 67-69, 1991

Antitumor cytotoxicity and other biologic properties of human adherent lymphokine activated killer a lak cells. Proceedings of the American Association for Cancer Research Annual Meeting 30: 370, 1989