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Supraependymal cell clusters in the rat hypothalamus


Anatomy & Embryology 168(3): 371-394
Supraependymal cell clusters in the rat hypothalamus
The fine structure of supraependymal cell clusters of the median eminence was studied with TEM [transmission electron microscopy]. Cluster cells were identified on the basis of ultrastructure and histochemical determination of glial fibrillar acidic protein (GFA). Phagocytic properties were also studied by means of intraventricular injections of HRP [horseradish peroxidase]. Neurons, neuroglia cells and degenerating ependyma- and glial cells were found. Extrusion of degenerating infundibular elements into the ventricle is a constant phenomenon but its precise localization and intensity are variable. The close proximity of the clusters to capillary loops is stressed. Because of the broken ependyma at the neck of the cluster, the permeability of the infundibular lining for HRP is increased. Clusters may be seen as sites lacking a brain-CSF barrier.

Accession: 006546034

PMID: 6201088

DOI: 10.1007/bf00304275

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