Surface antigens of rat liver epithelial cells grown in medium containing fetal bovine serum

Embleton, M. J.; Iype, P. T.

Cultured rat liver cells induced a strong antibody response in syngeneic rats, directed against fetal calf serum components which were incorporated into the liver cell surface from the cell-culture medium. This antibody could be removed by absorption with liver cells or glutaraldehyde-fixed fetal calf serum. The antigenic cross-reactivity observed in earlier studies with cultured cells treated with carcinogens may have been due to this fetal calf serum component.