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Surface area and crystallinity of Form A of chloramphenicol palmitic and stearic esters: which one is the limiting factor in the enzymatic hydrolysis?

Surface area and crystallinity of Form A of chloramphenicol palmitic and stearic esters: which one is the limiting factor in the enzymatic hydrolysis?

Journal of Pharmacy and Pharmacology 39(12): 1041-1043

Chloramphenicol stearic and palmitic esters in the polymorphic Form A, when ground for 85 h showed an in -vitro enzymatichydrolysis rate constant (Khydr), the value of which was the same as that of a commercial Form B. The increase in the rate of the enzymatic hydrolysis was not related to the specific surface area as shown by the fact that the micronized Form A, having a higher specific surface area value than ground Form A, showed the same Khydr as the unground Form A. The Khydr value of the ground Form A could be the result of an increase in the crystalline disorder brought about by the grinding process.

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Accession: 006546581

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PMID: 2894436

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