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Surface diffusion in human serum lipoproteins






Biochemical & Biophysical Research Communications 146(3): 1139-1145

Surface diffusion in human serum lipoproteins

From the viscosity dependence of the 31P NMR signals, the diffusion coefficients DT of phospholipid molecules in the surface monolayer of HDL, LDL and VLDL have been determined. DT for HDL3 and HDL2 are found to be 2.3 .times. 10-8 cm2/s and 1.8 .times. 10-8 cm2/s, respectively. These values are similar to values reported for diffusion of phospholipid molecules in phospholipid bilayers above the gel to liquid crystalline phase transition temperature. Viscosity dependence of [16, 16, 16-2H3]phosphatidylcholine incorporated into HDL2 yielded a value similar to that determined by 31P (DT = 1.9 .times. 10-8 cm2/s). Slower diffusion coefficient were measured for LDL2 and VLDL. VLDL had a value DT = 9.1 .times. 10-9 cm2/s. The diffusion coefficient for LDL2 was 1.4 .times. 10-9 cm2/s. Thus, diffusion of phospholipids in LDL2 is a full order of magnitude slower at 25.degree.C than diffusion of phospholipids in the HDLs.

Accession: 006546869

PMID: 3619919

DOI: 10.1016/0006-291x(87)90766-2

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