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Surface exposure of the amino terminal regions of the beta chain of the human fibrinogen


Thrombosis Research 14(4-5): 747-764
Surface exposure of the amino terminal regions of the beta chain of the human fibrinogen
The exposure of functionally critical areas of the B.beta. chain present in the NH2-terminal E domain of fibrinogen molecule was evaluated by quantitative immunochemical analysis. The anti-B.beta.1-118 antiserum specifically bound the B.beta.1-118 peptide and the B.beta. chain as well as intact fibrinogen and early catabolized forms of fibrinogen. The segment 1-53 of the B.beta. chain apparently contained all recognized surface accessible areas while the segment 54-118 was incorporated inside of the E domain of fibrinogen molecule. Detailed analysis allowed identification of determinants shared by fibrinogen and the B.beta.1-53 segment in sequences 1-21 and 43-53.


Accession: 006546944



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