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Surface exposure of the amino terminal regions of the beta chain of the human fibrinogen



Surface exposure of the amino terminal regions of the beta chain of the human fibrinogen



Thrombosis Research 14(4-5): 747-764



The exposure of functionally critical areas of the B.beta. chain present in the NH2-terminal E domain of fibrinogen molecule was evaluated by quantitative immunochemical analysis. The anti-B.beta.1-118 antiserum specifically bound the B.beta.1-118 peptide and the B.beta. chain as well as intact fibrinogen and early catabolized forms of fibrinogen. The segment 1-53 of the B.beta. chain apparently contained all recognized surface accessible areas while the segment 54-118 was incorporated inside of the E domain of fibrinogen molecule. Detailed analysis allowed identification of determinants shared by fibrinogen and the B.beta.1-53 segment in sequences 1-21 and 43-53.

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Accession: 006546944

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