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Susceptibility of yeast and some filamentous fungi to antifungal agents by a standardized micromethod



Susceptibility of yeast and some filamentous fungi to antifungal agents by a standardized micromethod



Bulletin de la Societe Francaise de Mycologie Medicale 16(2): 395-398



A standardized antifungigram method was used in routine by 7 laboratories for the determination of susceptibility of 476 yeasts strains with medical interest and 28 filamentous fungi to 7 antifungal agents at 2 concentrations. For yeasts, tioconazole showed the best in vitro activity, followed by ketoconazole, amphotericin B and the other imidazoles. Finally, 5-fluorocytosine was the least effective drug. However, results varied widely across species and antifungal agents. The susceptibility to antifungal agent observed in our study seems in correlation with results of treatment of mycosis, particularly for imidazoles, as reported in the literature. From technical point of view, this new antifungigram method takes a little space and was found to be easy to interpret and practical to use.

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Accession: 006553923

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