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Sympathectomy inhibits growth of a murine plasmacytoma tumor

Journal of the Autonomic Nervous System 13(2): 149-160

Sympathectomy inhibits growth of a murine plasmacytoma tumor

The effects of 6-hydroxydopamine (6-OHDA), N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) and anti-nerve growth factor (anti-NGF) on the development and growth of a tumor of non-neuronal origin were studied in mice. Murine LPC-1 plasmacytoma cells were grown either s.c. as solid tumors in the hindleg or i.p. in ascitic form. Growth of s.c. tumors was monitored by caliper measurements of the hindleg at the site of tumor cell inoculation; growth of ascitic tumors was followed by electrophoretic determination in plasma of the tumor associated protein IgG2a.kappa., M component. Adult mice were treated with 6-OHDA or DSP-4 6 h prior to tumor cell implantation; newborn mice were treated with anti-NGF and tumor cells were given 9 wk later. Both chemical- and immunosympathectomy significantly altered the growth pattern of solid and ascitic tumors (P < 0.0001). The effect of sympathectomy on the growth of solid tumors was most pronounced during the early phase of tumor growth. The effect of each drug treatment on tumor growth was not due to direct cytotoxic actions of the agents employed on tumor cells but the result of impairment of sympathetic functions. The sympathetic nervous system may play a role in tumor growth.

Accession: 006555705

PMID: 3926856

DOI: 10.1016/0165-1838(85)90031-1

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