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Syntheses and immuno adjuvant activity of some carbohydrate analogs of n acetylmuramyl l alanyl d iso glutamine



Syntheses and immuno adjuvant activity of some carbohydrate analogs of n acetylmuramyl l alanyl d iso glutamine



Agricultural & Biological Chemistry 44(6): 1301-1308



Carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine, such as 2-acetamido-2,6-dideoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose (11), 2-acetamido-6-amino-2,6-dideoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose (12) and 2-acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)D-xylopyranose (18) were synthesized and their immunoadjuvant activities [in guinea pigs] were examined to clarify their structural requirements for activity in the carbohydrate moiety.

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Accession: 006559459

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Related references

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