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Syntheses and in vitro antimicrobial evaluation some benzimidazol 2 ylmethylthioureas benzimidazol 2 ylacetylthiosemicarbazides and products of their condensation with monochloroacetic acid



Syntheses and in vitro antimicrobial evaluation some benzimidazol 2 ylmethylthioureas benzimidazol 2 ylacetylthiosemicarbazides and products of their condensation with monochloroacetic acid



Die Pharmazie 41(7): 475-478



N-Benzimidazol-2-ylacetyl-N'-[alkyl- and arylthio (carbamoyl)]hydrazines and N-benzimidazol-2-ylmethyl-N'-alkyl- and -arylthioureas were subjected to condensation with monochloroacetic acid to afford N-benzimidazol-2-ylacetyl-N'-2,3,4,5-tetrahydro-4-oxo-3-alkyl- and -arylthiazol-2-ylidenehydrazines and 3-benzimidazol-2-ylmethyl-2-alkyl- and arylimino-2,3-dihydrothiazol-4-(5H)ones, respectively. In preliminary antimicrobial testing, some compounds turned out to have significant activity against Staphylococcus aureus.

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Accession: 006559460

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