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Syntheses of a drug acting on the circulatory system 4. stereoselective reduction of 2 amino 1 propanones possessing hetero cycles at 1 position with sodium boro hydride studies on the syntheses of hetero cyclic compounds 852



Syntheses of a drug acting on the circulatory system 4. stereoselective reduction of 2 amino 1 propanones possessing hetero cycles at 1 position with sodium boro hydride studies on the syntheses of hetero cyclic compounds 852



Yakugaku Zasshi 101(5): 421-430



Stereoselective reduction of 2-amino-1-propanones having heterocycles as substituent was examined under several conditions. Sodium borohydride reduction of their hydrochlorides afforded stereoselectively the corresponding erythro-alcohols, and the same results are obtained by the reduction with diborane. This paper describes the effect of reaction temperature, solvent and molar ratio of reducing agent on the stereoselectivity on reduction. The compound produced may affect the circulatory system of animals.

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