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Syntheses of carbon 14 labeled prizidilol dihydrochloride



Syntheses of carbon 14 labeled prizidilol dihydrochloride



Journal of Labelled Compounds & Radiopharmaceuticals 22(9): 869-882



Two syntheses of radiolabeled prizidilol dihydrochloride ((DL)3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazino-pyridazine dihydrochloride) are described. A ten stage synthesis (Scheme 1) which gave [3,6-14C2] prizidilol dihydrochloride (10) in an overall yield of 0.91%. A later, alternative procedure (scheme 2) leading to [4,5-14C2]prizidilol dihydrochloride (16) with an overall radiochemical yield of 8%.

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