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Syntheses of the amides derived from hetero cyclic acids and hetero cyclic amines and their anti tumor activities

Syntheses of the amides derived from hetero cyclic acids and hetero cyclic amines and their anti tumor activities

Yakugaku Zasshi 96(4): 471-474

By the fusion method, 16 kinds of amide-type compounds were synthesized from the phenyl esters of heterocyclic acids and heterocyclic amines, and their antitumor activities were examined with Ehrlich ascites carcinoma and Crocker sarcoma-180 in mice. None had a strong antitumor activity but 7 of the test compounds, 2-isonicotinoylamino-1,3,4-thiadiazole, 2-nicotinoylamino-5-isopropyl-1,3,4-thiadiazole, 2-isonicotinoylamino-5-isopropyl-1,3,4-thiadiazole, 2-(.alpha.-thenoylamino)-5-isopropyl-1,3,4-thiadiazole, 2-(.alpha.-furoylamino)-5-isopropyl-1,3,4-thiadiazole, 2-isonicotinoylamino-5-isobutyl-1,3,4-thiadiazole and 2-(.alpha.-furoylamino)-5-isobutyl-1,3,4-thiadiazole, had a moderate to slight antitumor activity against these solid tumors. All these effective compounds were the derivatives of 2-amino-1,3,4-thiadiazole.

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Accession: 006559932

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PMID: 945828

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