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Synthesis and anti convulsant activity of 7 oxa bi cyclo 2.2.1 heptane derivatives 1. n alkyl n aryl and n hetero aryl derivatives of 3 6 epoxy hexa hydro phthalimide



Synthesis and anti convulsant activity of 7 oxa bi cyclo 2.2.1 heptane derivatives 1. n alkyl n aryl and n hetero aryl derivatives of 3 6 epoxy hexa hydro phthalimide



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 22(2): 131-135



N-substituted 3,6-epoxyhexahydrophathalimides (61) were prepared by the condensation of the appropriately substituted alkyl, aryl and heteroarylamines with exo-cis-3,6-epoxyhexahydrophthalic anhydride (2). Some of the compounds exhibit moderate anticonvulsant activity in electroshock, metrazole, strychnine and picrotoxin induced convulsions [in mice].

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