+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Synthesis and anti convulsant activity of 7 oxa bi cyclo 2.2.1 heptane derivatives 2. n alkyl n aryl and n hetero aryl derivatives of 3 6 epoxy hexa hydro phthalic acid amide



Synthesis and anti convulsant activity of 7 oxa bi cyclo 2.2.1 heptane derivatives 2. n alkyl n aryl and n hetero aryl derivatives of 3 6 epoxy hexa hydro phthalic acid amide



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 22(2): 136-139



N-substituted 3,6-epoxyhexahydrophthalic acid amides (.apprx. 50) were prepared by the reaction of exo-cis-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride with primary amines in benzene. Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions in mice. Several compounds were superior to ethosuximide and sodium valproate in anti-electroshock and anti-metrazole test systems.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006560223

Download citation: RISBibTeXText


Related references

Synthesis and anti convulsant activity of 7 oxa bi cyclo 2.2.1 heptane derivatives 1. n alkyl n aryl and n hetero aryl derivatives of 3 6 epoxy hexa hydro phthalimide. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 22(2): 131-135, 1983

Synthesis of hexa hydro bis benzodipyrazolones hexa hydro bis benzodiazepinone and di thio pyrimidoquinazolinetetrone di ethyl 1 4 cyclo hexanedione 2 5 dicarboxylate bis aryl azo benzodipyrazolone 1 2 4 5 cyclo hexatetrone 2 5 bis aryl hydrazone hydrazine diazonium salt acid hydrazide o phenylenediamine thio urea japp klingemann reaction. Zeitschrift fuer Naturforschung Teil B Anorganische Chemie Organische Chemie 34(1): 95-98, 1979

Studies on anti-Candida agents with a pyrrole moiety. Synthesis and microbiological activity of some [(1-alkyl),(1-aryl) and (1-benzyl)-5-aryl-3-carboxamido-2-methyl]pyrrole derivatives. Farmaco 47(7-8): 1047-1053, 1992

Thiazole derivatives part 1 synthesis and anti inflammatory activity of some 2 alkyl or aryl 2 aryl 4 methyl 4 5 bi thiazolyls and 2 amino substituted amino 2 aryl 4 methyl 4 5 bi thiazolyls. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 14(7): 552-555, 1976

Benzothiazole derivatives part 8 synthesis of some 2 4 alkyl or aryl 2 thiazolyl benzothiazoles and 12 4 alkyl or aryl 2 thiazolylamino benzothiazoles as potential anti inflammatory agents. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 15(2): 121-124, 1977

Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles. Journal of Medicinal Chemistry 14(10): 1000-1003, 1971

Deca hydro quinoline derivatives part 4 4 cyclo hexyl 4 phenyl 4 aralkyl and 4 hetero aryl deca hydro 4 quinolinols and related esters. European Journal of Medicinal Chemistry 10(3): 236-238, 1975

Synthesis of 5-aryl-1,3-dimethyl-6-(alkyl- or aryl-amino) furo [2,3-d]pyrimidine derivatives by reaction between isocyanides and pyridinecarbaldehydes in the presence of 1,3-dimethylbarbituric acid. Molecular Diversity 15(1): 227-231, 2011

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite. Angewandte Chemie 54(46): 13571-5, 2015

Synthesis, anti-inflammatory activity and metabolism of alkyl aryl ketones and their derivatives. Pharmaceutical Chemistry Journal 23(12): 990-995, 1989

The chemical constituents of rutaceous plants 51. development of a versatile method for the synthesis of anti tumor active benzo c phenanthridine alkaloids 3. detailed examination of the synthesis of 2 aryl 1 formamido 1 2 3 4 tetra hydro naphthalene from 2 aryl 1 tetralone derivatives/. Chemical and Pharmaceutical Bulletin 31(9): 3056-3073, 1983

Anti convulsant activity of n substituted derivatives of 1 anilino cyclo hexane 1 amide. Indian Journal of Pharmacology 14(2): 191-200, 1982

Synthesis of novel 1,2,3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity. European Journal of Medicinal Chemistry 80: 184-191, 2014

Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. Journal of Medicinal Chemistry 48(16): 5140-5153, 2005

Synthesis of new derivatives of 1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimidin-5-one active in CNS. Part 2. Synthesis and results of preliminary pharmacological screening of 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimid in-5- ones. Acta Poloniae Pharmaceutica 56(3): 215-219, 2000