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Synthesis and anti convulsive activity of 4 phenyl 2 pyrrolidone 1 acetic acid amides



Synthesis and anti convulsive activity of 4 phenyl 2 pyrrolidone 1 acetic acid amides



Khimiko-Farmatsevticheskii Zhurnal 14(11): 43-48



The following compounds were synthesized: 4-phenyl-2-pyrrolidone-3-carboxylic acid; 4-phenyl-2-pyrrolidone; ethyl-/4-phenyl-2-pyrrolidone-2-acetate; 4-phenyl-2-pyrrolidone-2-acetic acid amide (I); 4-phenyl-2-pyrrolidone-1-acetic acid hydrazide (Ib); 4-phenyl-2-pyrrolidone-l-acetic acid; 4-phenyl-2-pyrrolidone-1-acetic acid cyclohexylamide (Ic); 4-phenyl-2-pyrrolidone-1-acetic acid-1-adamantylamide (Id); 4-phenyl-2-pyrrolidone-1-acetic acid-2-adamantylamide (Ie). Data on the anticonvulsive action of amides of Ia-e, morpholep, phenylpyrrolidone and piracetam in mice showed that activity is dependent on structure.

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