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Synthesis and anti inflammatory activity of substituted alpha amino acetophenone hydro chlorides



Synthesis and anti inflammatory activity of substituted alpha amino acetophenone hydro chlorides



Khimiko-Farmatsevticheskii Zhurnal 17(10): 1201-1203



Substituted .alpha.-aminoacetophenones were synthesized by a reaction between .alpha.-bromacetophenones and amines. The reaction products were transformed into hydrochlorides and iodomethylates. Their antipyretic, analgesic and antiinflammatory properties were studied in a model of yeast fever, as well as in acute carrageenan inflammation of rat's paw and chronic proliferative inflammation. The compounds possessed low toxicity when tested in mice. Fluoro- and bromo- derivatives of .gamma.-aminoketones inhibited the development of granular tissue, but the corresponding chloro- derivatives did not possess such activity. The compounds did not possess antiinflammatory, antipyretic and analgesic properties.

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