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Synthesis and central nervous system activity of 4 arylideneamino n n diphenyl benzamides 1 p n n di phenylcarbamoylphenyl 3 p substituted phenyl thio ureas and 6 substituted 3 n 3h 2 methyl 4 oxo 3 quinazolylaminomethyl 2 oxo thio benzoxazoles



Synthesis and central nervous system activity of 4 arylideneamino n n diphenyl benzamides 1 p n n di phenylcarbamoylphenyl 3 p substituted phenyl thio ureas and 6 substituted 3 n 3h 2 methyl 4 oxo 3 quinazolylaminomethyl 2 oxo thio benzoxazoles



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 21(12): 1110-1113



4-Arylideneamino-N,N,-diphenylbenzamides (IIIa-h), 1-[p-(N,N-diphenylcarbamoyl)phenyl]-3-(p-substituted phenyl)thioureas (IVa-d) and 6-substituted 3-[N-(3H-2-methyl-4-oxo-3-quinazolylamino)methyl]-2-oxo-/thio-benzoxazoles (Va-d) were synthesized from 4-amino-N,N-diphenylbezamide (IIa). Thioureas IVe-h and benzoxazoles Ve-h were prepared from 2-aminoquinazolin-4(3H)-one (IIb). Compounds III, IV and V were psychotropic and nontoxic. [During testing in mice all compounds were grossly CNS depressant except compounds IIId, IIIe and IIIf which were CNS stimulant.].

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