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Synthesis and study of 2 substituted 4 4 methoxy 3 2 hydroxy 5 halo or 5 nitrobenzylideneaminophenyl thiazoles hydro chlorides for in vitro anti tuberculosis activity part 2



Synthesis and study of 2 substituted 4 4 methoxy 3 2 hydroxy 5 halo or 5 nitrobenzylideneaminophenyl thiazoles hydro chlorides for in vitro anti tuberculosis activity part 2



Bulletin of Haffkine Institute 6(1): 36-39



In view of antituberculosis activity displayed by the azomethine derivatives derived from p-N, N-dimethyl-aminobenzaldehyde and p-acetamidobenzaldehyde with 2-aryl-4-(3'-amino-4'-methoxyphenyl) thiazoles (I) new azomethine derivatives were prepared in the present work, from 5-halo- and 5-nitrosalicylaldehydes and above thiazole moiety I. Thirty-two derivatives were prepared and screened for in vitro antituberculosis activity. Twenty-one compounds showed activity and inhibited the growth of Mycobacterium tuberculosis at < 5 .mu.g/ml. Three compounds had a minimum inhibitory concentration of 1 .mu.g/ml.

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