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Synthesis of 7 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 yl 3 hydroxy 5 oxo 5 carbon 13 heptanoic acid and trans 6 2 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 ylethyl 3 4 5 6 tetrahydro 6 carbon 13 4 hydroxy 2h pyran 2 one



Synthesis of 7 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 yl 3 hydroxy 5 oxo 5 carbon 13 heptanoic acid and trans 6 2 4' fluoro 3 3' 5 trimethyl 1 1' biphenyl 2 ylethyl 3 4 5 6 tetrahydro 6 carbon 13 4 hydroxy 2h pyran 2 one



Journal of Labelled Compounds and Radiopharmaceuticals 24(7): 839-850



The title compounds are potent HMG-CoA reductase inhibitors. A 13C-label was introduced into these compounds to permit probing of their interaction with HMG-CoA reductase by 13C NMR techniques in the presence and absence of added NADPH.

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